Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats.

ABSTRACT:

Background

Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments. In our recent research we demonstrated that CM has nephroprotective potentials in diabetes mellitus, hypertension and renal disorders. However, to the best of our knowledge, no systematic study concerning its toxicity profile has been reported.

Aim of the study

The study carried out to evaluates the potential toxicity of the hydroalcoholic extract from leaves of the CM, through the method of acute and sub-chronic oral administration in rats.

Materials and methods

During the acute toxicity study, male and female rats were orally administrated with CM extract at singl

SUBMITTER: Kpemissi M 

PROVIDER: S-EPMC6976914 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature