The type of bottleneck matters: Insights into the deleterious variation landscape of small managed populations.

ABSTRACT: Predictions about the consequences of a small population size on genetic and deleterious variation are fundamental to population genetics. As small populations are more affected by genetic drift, purifying selection acting against deleterious alleles is predicted to be less efficient, therefore increasing the risk of inbreeding depression. However, the extent to which small populations are subjected to genetic drift depends on the nature and time frame in which the bottleneck occurs. Domesticated species are an excellent model to investigate the consequences of population bottlenecks on genetic and deleterious variation in small populations. This is because their history is dominated by known bottlenecks associated with domestication, breed formation and intense selective breeding. Here, w

SUBMITTER: Bortoluzzi C 

PROVIDER: S-EPMC6976952 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature