Can IL-6 predict the development of fat embolism in polytrauma? A rabbit model pilot experimental study.

ABSTRACT:

Background

There are few studies in the literature that correlates the level of IL-6 with fat embolism syndrome (FES). But there is no conclusive correlative evidence of its specific relation to the establishment of FES. Also it is a proven fact that polytrauma due to its associated multiple long bone fracture and/or associated shock can predispose an individual to FES. By hypothesizing that polytrauma induces Fat Embolism in the animal; it was considered worthwhile to study the association of IL-6 in polytrauma induced Fat Embolism (FE) and to compare it with induced FE by injecting fatty acids in rabbits.

Materials and methods

An animal study was conducted in 32 New Zealand white rabbits. The animals were divided into 3 groups: control, fat embolism and polytrauma group. W

SUBMITTER: Karthick SR 

PROVIDER: S-EPMC6976997 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature