Practical application of Six Sigma management in analytical biochemistry processes in clinical settings.

ABSTRACT:

Background

Six Sigma methodology with a zero-defect goal has long been applied in commercial settings and was utilized in this study to assure/improve the quality of various analytes.

Methods

Daily internal quality control (QC) and external quality assessment data were collected and analyzed by calculating the sigma (σ) values for 19 analytes based on the coefficient of variation, bias, and total error allowable. Standardized QC sigma charts were established with these parameters. Quality goal index (QGI) analysis and root cause analysis (RCA) were used to discover potential problems for the analytes.

Results

Five analytes with σ ≥ 6 achieved world-class performance, and only the Westgard rule (1_3s ) with one control measurement at two QC material levels (N

SUBMITTER: Zhou B 

PROVIDER: S-EPMC6977137 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature