Association of vitamin D genetic pathway with asthma susceptibility in the Kurdish population.

ABSTRACT:

Background

Vitamin D (Vit D) function in asthma progression has been studied well. The effects of genetic variations in Vit D pathway molecules have been also studied, although the results are contradicted. In the present study, for the first time we examined the Vit D pathway molecules included serum Vit D and vitamin D-binding protein (VDBP) and also genetic variations in the vitamin D receptor (VDR) and VDBP in a Kurdish population with asthma.

Methods

An enzyme-linked immunosorbent assay (ELISA) method was used to measure the serum Vit D and VDBP. VDR rs1544410 and rs2228570 and VDBP rs7041 were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results

The serum level of Vit D significantly decreased in asthmatic patients v

SUBMITTER: Nasiri-Kalmarzi R 

PROVIDER: S-EPMC6977155 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature