French lyophilized plasma versus normal saline for post-traumatic coagulopathy prevention and correction: PREHO-PLYO protocol for a multicenter randomized controlled clinical trial.

ABSTRACT:

Background

Post-trauma bleeding induces an acute deficiency in clotting factors, which promotes bleeding and hemorrhagic shock. However, early plasma administration may reduce the severity of trauma-induced coagulopathy (TIC). Unlike fresh frozen plasma, which requires specific hospital logistics, French lyophilized plasma (FLYP) is storable at room temperature and compatible with all blood types, supporting its use in prehospital emergency care. We aim to test the hypothesis that by attenuating TIC, FLYP administered by prehospital emergency physicians would benefit the severely injured civilian patient at risk for hemorrhagic shock.

Methods/design

This multicenter randomized clinical trial will include adults severely injured and at risk for hemorrhagic shock, with a systo

SUBMITTER: Jost D 

PROVIDER: S-EPMC6977230 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature