Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy.

ABSTRACT:

Background

We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant^®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. However, the immunological effect of adjuvants on immune cells from cancer patients undergoing chemotherapy remains to be demonstrated. Different adjuvants currently used in cancer vaccine clinical trials were evaluated in the present study on immune cells from cancer patients before and after chemotherapy in an ex vivo setting.

Methods

PBMCs were obtained from 4 healthy volunteers and 23 patients affected by either colon (OMA) or lung cancer (OT). The effect of CpG, Poly I:C, Imiquimod and RNA-based adjuvant (RNAdjuvant^®) was assessed usin

SUBMITTER: Mauriello A 

PROVIDER: S-EPMC6977281 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature