Therapy of Hypoparathyroidism With rhPTH(1-84): A Prospective, 8-Year Investigation of Efficacy and Safety.

ABSTRACT:

Context

Conventional treatment of hypoparathyroidism is associated with decreased renal function and increased bone mineral density (BMD).

Objective

To evaluate the effects of 8 years of recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] therapy on key biochemical and densitometric indices.

Design

Prospective open-label trial.

Setting

Tertiary medical center.

Participants

Twenty-four subjects with hypoparathyroidism.

Intervention

Treatment with rhPTH(1-84) for 8 years.

Main outcome measures

Supplemental calcium and vitamin D requirements, serum calcium and phosphorus levels, calcium-phosphate product, urinary calcium excretion, estimated glomerular filtration rate (eGFR) and BMD.

Results

PTH therapy was associated with progre

SUBMITTER: Tay YD 

PROVIDER: S-EPMC6977408 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature