Rhodium-catalyzed asymmetric intramolecular hydroarylation of allenes: access to functionalized benzocycles.

ABSTRACT: A rhodium-catalyzed regio- and enantioselective cyclization of tethered allenylbenzenes is reported. Employing a Rh^I/Josiphos catalytic system a diverse set of 6-membered, α-chiral benzocycles were obtained, scaffolds found in many bioactive compounds. Moreover, a gram scale reaction as well as the application of suitable transformations are demonstrated.

SUBMITTER: Berthold D 

PROVIDER: S-EPMC6977554 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature