Aging exacerbates neutrophil pathogenicity in ischemic stroke.

ABSTRACT: Ischemic stroke is major cause of disability and mortality worldwide, and aging is strong risk factor for poor post-stroke outcome. Neutrophils traffic rapidly to the brain following ischemic stroke, and recent evidence has suggested that aging may alter neutrophil function after tissue injury. In this study, we hypothesize that aging enhances the pro-inflammatory function of neutrophils, directly contributing to the poorer outcomes seen in aging patients. We utilized demographic data and biological specimens from ischemic stroke patients and an experimental mouse model to determine the correlation between age, neutrophil function and stroke outcomes. In ischemic stroke patients, age was associated with increased mortality and morbidity and higher levels of neutrophil-activating cytokines.

SUBMITTER: Roy-O'Reilly MA 

PROVIDER: S-EPMC6977697 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature