Hyponatraemia reversibly affects human myometrial contractility. An in vitro pilot study.

ABSTRACT:

Background

In a previous study we found a significant correlation between dystocia and hyponatraemia that developed during labour. The present study examined a possible causal relationship. In vitro studies often use area under the curve (AUC) determined by frequency and force of contractions as a measure of myometrial contractility. However, a phase portrait plot of isometric contraction, obtained by plotting the first derivate of contraction against force of contraction, could indicate that bi-or multiphasic contractions might be less effective compared to the smooth contractions.

Material and methods

Myometrial biopsies were obtained from 17 women undergoing elective caesarean section at term. Each biopsy was divided into 8 strips and mounted isometrically in a force tran

SUBMITTER: Moen V 

PROVIDER: S-EPMC6977732 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature