Early antiretroviral treatment of infants to attain HIV remission.

ABSTRACT:

Background

Studies in adults and children suggested that starting antiretroviral therapy (ART) soon after infection positively influences early events in HIV infection raising the possibility that remission may be achieved in some.

Methods

We designed an analytic treatment interruption (ATI) trial to test the hypothesis that a sizable minority of HIV-infected neonates who initiated ART <14 days of birth and maintained on ART would be able to maintain viral suppression when ART was withdrawn. To yield the target cohort for this trial, 73 HIV-infected neonates identified at one hospital in Johannesburg, South Africa, were initiated on ART <14 days of birth and maintained on ART tracking viral load (VL) decline and immune recovery (clinicaltrials.gov # NCT02431975).

Findings

SUBMITTER: Kuhn L 

PROVIDER: S-EPMC6978195 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature