The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy.

ABSTRACT:

Purpose

To assess the clinical-metabolic correlates of language impairment in a large sample of patients clinically diagnosed as corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPs).

Methods

We included 70 patients fulfilling current criteria for CBS (n = 33) or PSPs (n = 37). All subjects underwent clinical-neuropsychological and FDG-PET assessments at the time of diagnosis. The whole patient's cohort was grouped into three subgroups according to the language characteristics, i.e., (a) nfv-PPA; (b) subtle language impairments, LANG-; (c) no language deficits, NOL-. FDG-PET data were analysed using an optimized voxel-based SPM method at the single-subject and group levels in order to evaluate specific hypometabolic patterns and regional dysfunctiona

SUBMITTER: Dodich A 

PROVIDER: S-EPMC6978212 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature