Identification of a five-mRNA signature as a novel potential prognostic biomarker in pediatric Wilms tumor.

ABSTRACT:

Background

The aim of this study was to generate a prognostic model to predict survival outcome in pediatric Wilms tumor (WT).

Methods

The data including mRNA expression and clinical information of pediatric WT patients were downloaded from the Therapeutically Available Research to Generate Effective Treatments (TARGET) database. The differentially expressed genes were identified and a prognostic signature of pediatric WT was generated according to the results of univariate and multivariate Cox analysis. Receiver operating characteristic (ROC) curve was used to evaluate the five-mRNA signature in pediatric Wilms tumor patients. Bootstrap test with 500 times was used to perform the internal validation.

Results

We identified 6,964 differentially expressed mRNAs associat

SUBMITTER: Lin XD 

PROVIDER: S-EPMC6978231 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature