Investigation of the STOX1 polymorphism on lumbar disc herniation.

ABSTRACT:

Background

Lumbar disc herniation (LDH) is a common musculoskeletal disorder affliction and associated with several genes polymorphism. Storkhead box 1 (STOX1) gene is a transcriptional factor related with several signaling pathways including inflammatory pathway. However, little is known about single-nucleotide polymorphisms (SNPs) of STOX1 associated with LDH risk.

Methods

We conducted a case-control study among 508 LDH cases and well-matched 508 controls, and six candidate SNPs in STOX1 were genotyped by Agena MassARRAY. Chi-squared test, genetic model, and haploview analysis were used to evaluate associations. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression.

Results

In the allelic model analysis, we found t

SUBMITTER: Yang X 

PROVIDER: S-EPMC6978251 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature