Altered putamen and cerebellum connectivity among different subtypes of Parkinson's disease.

ABSTRACT:

Objective

Impairment of basal ganglia (BG)-thalamo-cortical circuit causes various symptoms of Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns of putamen among PD subtypes and healthy control (HC) and explored their clinical significance.

Methods

A total of 16 patients with tremor-dominant (TD) PD, 23 patients with postural instability and gait difficulty-dominant (PIGD) PD, and 31 HC that underwent functional magnetic resonance imaging were observed. Voxel-wise FC analysis was performed by computing correlation between bilateral putamen and other voxels within the brain. Correlation analysis was performed between FC strength and clinical symptoms.

Results

Compared with PIGD group, TD group showed increased FC between left putamen a

SUBMITTER: Shen B 

PROVIDER: S-EPMC6978269 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature