Monoamino oxidase alleles correlate with the presence of essential hypertension among hypogonadic patients.

ABSTRACT:

Background

Monoamine oxidase (MAO) activity has been traditionally implicated in blood pressure through its effects on biogenic amine levels such as catecholamines, serotonin, and dopamine. Nowadays, this role is considered relegated to side-effects such as orthostatic hypotension and/or hypertensive crisis derived from MAO-inhibitory treatments in patients with psychiatric disease.

Methods

In the present work we have found an association between a polymorphic variant of MAOB gene and arterial hypertension in obese hypogonadic patients. The study cases comprised a series of 219 nondiabetic males with a body mass index ≥30 kg/m² and aged <45 years. Hypogonadism was defined as subnormal testosterone concentrations, when free testosterone values ranged <65 pg/ml.

SUBMITTER: Royo JL 

PROVIDER: S-EPMC6978270 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature