H₂S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo.

ABSTRACT: Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H₂S-activatable NIR afterglow probe (F1²⁺-ANP). F1²⁺-ANP displays a fast reaction rate (1563 ± 141 M^-1 s^-1) and large afterglow turn-on ratio (~122-fold) toward H₂S, enabling high-sensitivity and -specificity measurement of H₂S concen

SUBMITTER: Wu L 

PROVIDER: S-EPMC6978336 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature