Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4⁺ T cells.

ABSTRACT: In immune-mediated hepatitis, type 2 innate lymphoid cells (ILC2) as well as effector CD4⁺ T cells have been shown to drive disease pathology. However, less is known about mechanisms involved in the regulation of ILC2 function during liver inflammation. We showed that in homeostasis, hepatic ILC2 constituted a very small population with a naive, inactive phenotype. During immune-mediated hepatitis, the cytokines IL-33 and IFNγ were expressed in liver tissue. IL-33 induced strong activation and expression of type 2 cytokines as well as IL-6 by hepatic ILC2 while IFNγ suppressed cytokine production. Interestingly, this inhibitory effect was overcome by IL-33. The phenotype of activated hepatic ILC2 were stable since they did not show functional plasticity in response to liver infl

SUBMITTER: Steinmann S 

PROVIDER: S-EPMC6978388 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature