Gene-by-gene interactions associated with the risk of conotruncal heart defects.

ABSTRACT:

Background

The development of conotruncal heart defects (CTDs) involves a complex relationship among genetic variants and maternal lifestyle factors. In this article, we focused on the interactions between 13 candidate genes within folate, homocysteine, and transsulfuration pathways for potential association with CTD risk.

Methods

Targeted sequencing was used for 328 case-parental triads enrolled in the National Birth Defects Prevention Study (NBDPS). To evaluate the interaction of two genes, we applied a conditional logistic regression model for all possible SNP pairs within two respective genes by contrasting the affected infants with their pseudo-controls. The findings were replicated in an independent sample of 86 NBDPS case-parental triads genotyped by DNA microarrays.

SUBMITTER: Lyu C 

PROVIDER: S-EPMC6978401 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature