Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

ABSTRACT: While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.

SUBMITTER: Chockanathan U 

PROVIDER: S-EPMC6978514 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature