The impact of multiple myeloma induction therapy on hematopoietic stem cell mobilization and collection: 25-year experience.

ABSTRACT: While first-line induction therapy for patients with multiple myeloma has changed over the years, autologous hematopoietic stem cell transplantation still plays a significant role, improving both depth of response and progression-free survival of myeloma patients. Our 25-year experience in mobilizing hematopoietic stem and progenitor cells for 472 transplant-eligible myeloma patients was retrospectively reviewed. Patients were stratified according to the remission induction therapy received, and the outcomes were compared among the cohorts that received vincristine, adriamycin and dexamethasone (VAD) (n=232), bortezomib and dexamethasone (BD) (n=86), cyclophosphamide, bortezomib and dexamethasone (CyBorD) (n=82) and other regimens (n=67). Cyclophosphamide plus granulocyte colony-stimulatin

SUBMITTER: Figueiredo A 

PROVIDER: S-EPMC6978537 | biostudies-literature | 2019 Oct - Dec

REPOSITORIES: biostudies-literature