COL^R Acinetobacter baumannii sRNA Signatures: Computational Comparative Identification and Biological Targets.

ABSTRACT: Multidrug-Resistant (MDR) and Extensively Drug Resistant (XDR) Acinetobacter baumannii (Ab) represent a serious cause of healthcare-associated infections worldwide. Currently, the available treatment options are very restricted and colistin-based therapies are last-line treatments of these infections, even though colistin resistant (COL^R) Ab have rarely been isolated yet. In bacteria, small non-coding RNAs (sRNAs) have been implicated in regulatory pathways of different biological functions, however, no knowledge exists about the sRNA role on the biological adaptation in COL^R Ab. Our study investigated two Italian XDR isogenic colistin-susceptible/resistant (COL^S/R) Ab strain-pairs to discover new sRNA signatures. Comparat

SUBMITTER: Cafiso V 

PROVIDER: S-EPMC6978653 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature