Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naive Mice.

ABSTRACT: Regulatory T cells (Tregs) are essential for the maintenance of gut homeostasis by suppressing conventional CD4⁺ helper T cells (Tconvs) that are activated by microbial antigens. Although thymus is the major source of the peripheral Tregs, peripheral conversion from Tconvs to Tregs have also been shown to occur under various experimental conditions. It remains less clear about the frequency of lineage conversion from Tconvs to Tregs in naïve animals. Here we used a newly established reporter system to track a group of post expansion Tregs (eTregs), which exhibited a stronger suppressive ability than the non-lineage marked Tregs. Notably, microbial antigens are the primary driver for the formation of eTregs. TCR repertoire analysis of Peyer's patch T cells revealed that eTregs ar

SUBMITTER: Zhu K 

PROVIDER: S-EPMC6978744 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature