The Acute Effects of Amyloid-Beta1-42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus.

ABSTRACT: Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms which drive its progression. Glutamate is the main excitatory neurotransmitter in the brain and plays an essential role in the normal function and excitability of neuronal networks. While previous studies have shown alterations in the function of the glutamatergic system in AD, the underlying etiology of beta amyloid (Aβ1-42) induced changes has not been explored. Here we have investigated the acute effects of stereotaxic hippocampal Aβ1-42 injection on specific glutamatergic receptors and transporters in the mouse hippocampus, using immunohistochemistry and confo

SUBMITTER: Yeung JHY 

PROVIDER: S-EPMC6978747 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature