Precision Anisotropic Brush Polymers by Sequence Controlled Chemistry.

ABSTRACT: The programming of nanomaterials at molecular length-scales to control architecture and function represents a pinnacle in soft materials synthesis. Although elusive in synthetic materials, Nature has evolutionarily refined macromolecular synthesis with perfect atomic resolution across three-dimensional space that serves specific functions. We show that biomolecules, specifically proteins, provide an intrinsic macromolecular backbone for the construction of anisotropic brush polymers with monodisperse lengths via grafting-from strategy. Using human serum albumin as a model, its sequence was exploited to chemically transform a single cysteine, such that the expression of said functionality is asymmetrically placed along the backbone of the eventual brush polymer. This positional monofunction

SUBMITTER: Chen C 

PROVIDER: S-EPMC6978811 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature