Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance.

ABSTRACT: Variability in cortical neuronal responses to sensory stimuli and in perceptual decision making performance is substantial. Moment-to-moment fluctuations in waking state or arousal can account for much of this variability. Yet, this variability is rarely characterized across the full spectrum of waking states, leaving the characteristics of the optimal state for sensory processing unresolved. Using pupillometry in concert with extracellular multiunit and intracellular whole-cell recordings, we found that the magnitude and reliability of visually evoked responses in primary visual cortex (V1) of awake, passively behaving male mice increase as a function of arousal and are largest during sustained locomotion periods. During these high-arousal, sustained locomotion periods, cortical neuronal

SUBMITTER: Neske GT 

PROVIDER: S-EPMC6978938 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature