Differences in Short QT Syndrome Subtypes: A Systematic Literature Review and Pooled Analysis.

ABSTRACT:

Background

Short QT syndrome (SQTS) is a rare syndrome and affects different types of genes. However, data on differences of clinical profile and outcome of different SQTS types are sparse.

Methods

We conducted a pooled analysis of 110 SQTS patients. Patients have been diagnosed between 2000 and 2017 at our institution (n = 12) and revealed using a literature review (n = 98). 29 studies were identified by analysing systematic data bases (PubMed, Web of Science, Cochrane Libary, Cinahl).

Results

67 patients with genotype positive SQTS origin and 43 patients with genotype negative origin were found. A significant difference is documented between the sex with a higher predominance of male in genotype negative SQTS patients and predominance of females in genotype positive

SUBMITTER: Raschwitz LS 

PROVIDER: S-EPMC6979065 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature