Excessive BCAA regulates fat metabolism partially through the modification of m⁶A RNA methylation in weanling piglets.

ABSTRACT:

Background

Fat percentage and distribution in pigs are associated with their productive efficiency and meat quality. Dietary branched-chain amino acids (BCAA) regulate fat metabolism in weanling piglets with unknown mechanism. It is reported that N6-methyl-adenosine (m⁶A) is involved in fat metabolism in mice. The current study was designed to investigate the relationship between dietary branched-chain amino acids and fat metabolism through N6-methyl-adenosine (m⁶A) in weanling piglets.

Methods

A total of 18 healthy crossbred weaned piglets (Duroc × Landrace × Large White, 10.45 ± 0.41 kg) were divided into 3 treatments and were fed the low BCAA dose diet (L-BCAA), the normal dose BCAA diet (N-BCAA), or the high dose BCAA (H-BCAA) diet for 3 weeks.

R

SUBMITTER: Heng J 

PROVIDER: S-EPMC6979292 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature