Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.

ABSTRACT:

Background

Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clinical management of patients, also because the molecular mechanisms behind therapy resistance are not yet fully understood. In the present study, we therefore aimed to identify novel targets to intervene with therapy resistance using gene expression analysis of PCa co-culture spheroids where PCa cells are grown in the presence of cancer-associated fibroblasts (CAFs) and which have been previously shown to be a reliable model for antiandrogen resistance.

Methods

Gene expression changes of co-culture spheroids (LNCaP and DuCaP seeded together with CAFs) were ide

SUBMITTER: Neuwirt H 

PROVIDER: S-EPMC6979368 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature