Cost-Effectiveness of Treating Early to Moderate Stage Knee Osteoarthritis with Intra-articular Hyaluronic Acid Compared to Conservative Interventions.

ABSTRACT:

Introduction

Evidence has demonstrated greater benefit of intra-articular hyaluronic acid (IA-HA) within earlier stages of knee osteoarthritis (OA) rather than waiting for patients to have progressed to later stages of disease progression. High molecular weight (HMW) HA has also been shown to be more effective than low molecular weight (LMW) HA products in mild to moderate knee OA, providing an important distinction to make within the class of IA-HA therapies. The purpose of this study is to evaluate the cost-effectiveness of treating patients with knee OA with HMW HA compared to LMW and conservative treatment, while taking into account disease stage.

Methods

Decision analytic models were created for early/moderate, as well as late stage knee OA. Models for late stage knee O

SUBMITTER: Rosen J 

PROVIDER: S-EPMC6979456 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature