Integrating Computational Methods to Investigate the Macroecology of Microbiomes.

ABSTRACT: Studies in microbiology have long been mostly restricted to small spatial scales. However, recent technological advances, such as new sequencing methodologies, have ushered an era of large-scale sequencing of environmental DNA data from multiple biomes worldwide. These global datasets can now be used to explore long standing questions of microbial ecology. New methodological approaches and concepts are being developed to study such large-scale patterns in microbial communities, resulting in new perspectives that represent a significant advances for both microbiology and macroecology. Here, we identify and review important conceptual, computational, and methodological challenges and opportunities in microbial macroecology. Specifically, we discuss the challenges of handling and analyzing la

SUBMITTER: Mascarenhas R 

PROVIDER: S-EPMC6979972 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature