Fabrication of Functional Biomaterial Microstructures by in Situ Photopolymerization and Photodegradation.

ABSTRACT: The in situ fabrication of poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures within poly(dimethylsiloxane) (PDMS)-based microfluidic networks is a versatile technique that has enabled unique applications in biosensing, medical diagnostics, and the fundamental life sciences. Hydrogel structures have previously been patterned by the lithographic photopolymerization of PEGDA hydrogel forming solutions, a process that is confounded by oxygen-permeable PDMS. Here, we introduce an alternate PEG patterning technique that relies upon the optical sculpting of features by patterned light-induced erosion of photodegradable PEGDA deemed negative projection lithography. We quantitatively compared the hydrogel micropatterning fidelity of negative projection lithography to positive projec

SUBMITTER: LeValley PJ 

PROVIDER: S-EPMC6980224 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature