Complete histologic normalisation is associated with reduced risk of relapse among patients with ulcerative colitis in complete endoscopic remission.

ABSTRACT:

Background

Clinical and endoscopic remission are treatment targets in ulcerative colitis (UC). The value of histologic healing in altering clinical outcomes among patients with complete endoscopic healing is not well established.

Aim

To quantify the association between histologic activity and clinical relapse among patients with UC who were in complete endoscopic remission.

Methods

This study included patients with UC from a prospective registry who were in complete endoscopic remission. Histologic activity was quantified by a senior gastrointestinal pathologist. Histologic activity was defined as lack of normalisation (Geboes score > 0) as well as histologically active disease (Geboes score ≥2.1 and ≥3.1). The primary outcome was clinical relapse within 2 years. Mult

SUBMITTER: Cushing KC 

PROVIDER: S-EPMC6980269 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature