Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.

ABSTRACT: A mechanistic understanding of the pathology of psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences in information-processing impairments in patients with post-traumatic stress disorder (PTSD) could reveal phenotypes within the disorder. We found that a subgroup of patients with PTSD from two independent cohorts displayed both aberrant functional connectivity within the ventral attention network (VAN) as revealed by functional magnetic resonance imaging (fMRI) neuroimaging and impaired verbal memory on a word list learning task. This combined phenotype was not associated with differences in symptoms or comorbidities, but non

SUBMITTER: Etkin A 

PROVIDER: S-EPMC6980337 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature