Deep Learning Benchmarks on L1000 Gene Expression Data.

ABSTRACT: Gene expression data can offer deep, physiological insights beyond the static coding of the genome alone. We believe that realizing this potential requires specialized, high-capacity machine learning methods capable of using underlying biological structure, but the development of such models is hampered by the lack of published benchmark tasks and well characterized baselines. In this work, we establish such benchmarks and baselines by profiling many classifiers against biologically motivated tasks on two curated views of a large, public gene expression dataset (the LINCS corpus) and one privately produced dataset. We provide these two curated views of the public LINCS dataset and our benchmark tasks to enable direct comparisons to future methodological work and help spur deep learning met

SUBMITTER: McDermott MBA 

PROVIDER: S-EPMC6980363 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature