Randomized controlled study of aerosolized hypertonic xylitol versus hypertonic saline in hospitalized patients with pulmonary exacerbation of cystic fibrosis.

ABSTRACT:

Background

Cystic fibrosis (CF) lung disease is characterized by chronic bacterial infection and recurrent pulmonary exacerbations. Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration and augment innate immunity. We examined the safety and efficacy of aerosolized xylitol use for 2 weeks in subjects hospitalized with a pulmonary exacerbation of CF.

Methods

In a 2-week study, 60 subjects with cystic fibrosis and FEV₁ > 30% predicted were enrolled to receive aerosolized 7% hypertonic saline (4 ml) or 15% xylitol (5 ml) twice a day for 14 days. Outcomes assessed included change from baseline in FEV₁% predicted, change in sputum microbial density, revised CF quality of life questionnaire including the respiratory symptom score, t

SUBMITTER: Singh S 

PROVIDER: S-EPMC6980423 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature