Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation.

ABSTRACT: Migraine is one of the most disabling neurological diseases worldwide; however, the mechanisms underlying migraine headache are still not fully understood and current therapies for such pain are inadequate. It has been suggested that inflammation and neuroimmune modulation in the gastrointestinal tract could play an important role in the pathogenesis of migraine headache, but how gut microbiomes contribute to migraine headache is unclear. In the present study, we investigated the effect of gut microbiota dysbiosis on migraine-like pain using broad-spectrum antibiotics and germ-free (GF) mice. We observed that antibiotics treatment-prolonged nitroglycerin (NTG)-induced acute migraine-like pain in wild-type (WT) mice and the pain prolongation was completely blocked by genetic deletion of tum

SUBMITTER: Tang Y 

PROVIDER: S-EPMC6980505 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature