Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young males independent of obesity.

ABSTRACT:

Background

Obesity is a major risk factor for many chronic diseases, including reduced lung function. The role of polymorphisms of the adiponectin gene, though linked with cardiometabolic consequences of obesity, has not been studied in relation to lung function.

Objectives

The aim of this study is to examine polymorphisms in the ADIPOQ, ADIPOR1, and ADIPOR2 genes in relation to adiponectin serum levels, BMI, and adiposity in 18-year old Cypriot males, as well as determine whether BMI, adipokines levels and polymorphisms in adipokine related genes are associated with lung function levels.

Results

From the participants, 8% were classified as obese, 22% as overweight, and the remaining 71% as normal. We found that rs266729 and rs1501299 in ADIPOQ and rs10920531 in ADIPO

SUBMITTER: Christodoulou A 

PROVIDER: S-EPMC6980555 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature