Ontology highlight
ABSTRACT:
SUBMITTER: Volc SM
PROVIDER: S-EPMC6980636 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
PloS one 20200124 1
Sarcomas represent less than 1% of all solid neoplasms in adults and over 20% in children. Their etiology is unclear, but genetic susceptibility plays an important role in this scenario. Sarcoma is central in Li-Fraumeni Syndrome (LFS), a familial predisposition cancer syndrome. In Brazil, the high prevalence of p.Arg337His mutations in the TP53 gene brings about a unique condition: a cluster of LFS. In the present work, we studied 502 sarcoma patients not selected by age or family history in an ...[more]