Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry.

ABSTRACT:

Background

Striatal neuroadaptations are regarded to play an important role in the progression from voluntary to compulsive use of addictive substances and provide a promising target for the identification of neuroimaging biomarkers. Recent advances in surface-based computational analysis enable morphological assessment linking variations in global and local striatal shape to duration and magnitude of substance use with a degree of sensitivity that exceeds standard volumetric analysis.

Methods

This study used a new segmentation methodology coupled with local surface-based indices of surface area and displacement to provide a comprehensive structural characterization of the striatum in 34 patients entering treatment for substance use disorder (SUD) and 49 controls, and to exa

SUBMITTER: Copersino ML 

PROVIDER: S-EPMC6980652 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature