CO₂ per se activates carbon dioxide receptors.

ABSTRACT: Carbon dioxide has been used in traps for more than six decades to monitor mosquito populations and help make informed vector management decisions. CO₂ is sensed by gustatory receptors (GRs) housed in neurons in the maxillary palps. CO₂-sensitive GRs have been identified from the vinegar fly and mosquitoes, but it remains to be resolved whether these receptors respond to CO₂ or bicarbonate. As opposed to the vinegar fly, mosquitoes have three GR subunits, but it is assumed that subunits GR1 and GR3 form functional receptors. In our attempt to identify the chemical species that bind these receptors, we discovered that GR2 and GR3 are essential for receptor function and that GR1 appears to function as a modulator. While Xenopus oocytes coexpressing Culex quin

SUBMITTER: Xu P 

PROVIDER: S-EPMC6980743 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature