Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma.

ABSTRACT:

Purpose

Somatic mutations in cancer cells can give rise to novel protein sequences that can be presented by antigen-presenting cells as neoantigens to the host immune system. Tumor neoantigens represent excellent targets for immunotherapy, due to their specific expression in cancer tissue. Despite the widespread use of immunomodulatory drugs and immunotherapies that recharge T and NK cells, there has been no direct evidence that neoantigen-specific T-cell responses are elicited in multiple myeloma.

Experimental design

Using next-generation sequencing data we describe the landscape of neo-antigens in 184 patients with multiple myeloma and successfully validate neoantigen-specific T cells in patients with multiple myeloma and support the feasibility of neoantigen-based therape

SUBMITTER: Perumal D 

PROVIDER: S-EPMC6980765 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature