Metabolomics and microbial composition increase insight into the impact of dietary differences in cirrhosis.

ABSTRACT:

Background & aims

Dietary changes can modulate gut microbiota and interact with cirrhosis. Our prior study demonstrated that microbial diversity was higher in cirrhotics from Turkish vs the USA, which was associated with lower risk of 90-day hospitalizations. We aimed to define gut microbial functional and metabolomic changes to increase insight into benefits of the Mediterranean compared to Western diets.

Methods

In all, 139 Turkish (46 controls/50 compensated/43 decompensated) and 157 American subjects (48 controls/59 compensated/50 decompensated) were studied. Turkish subjects consumed a modified Mediterranean diet with daily fermented milk intake, whereas Americans consumed a Western diet. Predicted gut microbial functionalities and plasma metabolomics were compared betw

SUBMITTER: Cox IJ 

PROVIDER: S-EPMC6980909 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature