Antiretroviral Drugs Promote Amyloidogenesis by De-Acidifying Endolysosomes.

ABSTRACT: Antiretroviral therapeutics (ART) have effectively increased the long-term survival of HIV-1 infected individuals. However, the prevalence of HIV-1 associated neurocognitive disorders (HAND) has increased and so too have clinical manifestations and pathological features of Alzheimer's disease (AD) in people living with HIV-1/AIDS. Although underlying mechanisms are not clear, chronic exposure to ART drugs has been implicated in the development of AD-like symptoms and pathology. ART drugs are categorized according to their mechanism of action in controlling HIV-1 levels. All ART drugs are organic compounds that can be classified as being either weak acids or weak bases, and these physicochemical properties may be of central importance to ART drug-induced AD-like pathology because weak bases

SUBMITTER: Hui L 

PROVIDER: S-EPMC6981001 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature