Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures.

ABSTRACT:

Background

The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake affects resting state functional connectivity (rsFC) between the nucleus accumbens (NAc) and these regions will improve mechanistic understanding of alcohol's neurobehavioral effects, including the neural overlap between acute alcohol effects and pain processing.

Methods

Fifteen healthy social drinkers (10 women; age: 25-45 years) were included in the study. Participants completed one session in which they consumed an alcohol dose targeting a breath alcohol con

SUBMITTER: Boissoneault J 

PROVIDER: S-EPMC6981011 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature