The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.

ABSTRACT: The striatum with a number of dopamine containing neurons, receiving projections from the substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative diseases of motor and memory function. Additionally, oxidative damage to nucleic acid may be vital in the development of age-associated neurodegeneration. The metabolism of dopamine is recognized as one of the sources of reactive oxygen species through the Fenton mechanism. The proposed interactions of oxidative insults and dopamine in the striatum during the progression of diseases are the hypotheses of most interest to our study. This study investigated the possibility of significant interactions between these molecules that are involved in the late-stage of Alzheimer's disease (AD), Parkinson disease (PD), Parki

SUBMITTER: Li H 

PROVIDER: S-EPMC6981021 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature