Imaging acquisition technique influences interpretation of positron emission tomography vascular activity in large-vessel vasculitis.

ABSTRACT:

Objectives

To determine the impact of imaging acquisition time on interpretation of disease activity on ¹⁸F-fluorodeoxyglucose positron emission tomography (PET) in large-vessel vasculitis (LVV) and assess the relationship between clinical features and image acquisition time.

Methods

Patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK) were recruited into a prospective, observational cohort. After a single injection of FDG, all patients underwent two sequential PET scans at one and two-hour time points. Images were interpreted for active vasculitis by subjective assessment, qualitative assessment, and semi-quantitative assessment. Agreement was assessed by percent agreement, Cohen's kappa, and McNemar's test. Multivariable logistic regression id

SUBMITTER: Quinn KA 

PROVIDER: S-EPMC6981042 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature