Circulating miRNAs and Risk of Sudden Death in Patients With Coronary Heart Disease.

ABSTRACT:

Objectives

This study evaluated whether plasma miRNAs were specifically associated with sudden cardiac and/or arrhythmic death (SCD) in a cohort of patients with coronary heart disease (CHD), most of whom were without primary prevention implantable cardioverter-defibrillators.

Background

Novel biomarkers for sudden death risk stratification are needed in patients with CHD to more precisely target preventive therapies, such as implantable cardioverter-defibrillators. miRNAs have been implicated in regulating inflammation and cardiac fibrosis in cells, and plasma miRNAs have been shown to predict cardiovascular death in patients with CHD.

Methods

We performed a nested case control study within a multicenter cohort of 5,956 patients with CHD followed prospectively for SC

SUBMITTER: Silverman MG 

PROVIDER: S-EPMC6981228 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature