YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
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ABSTRACT:
SUBMITTER: Tanaka H
PROVIDER: S-EPMC6981281 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Tanaka Hikari H Homma Hidenori H Fujita Kyota K Kondo Kanoh K Yamada Shingo S Jin Xiaocen X Waragai Masaaki M Ohtomo Gaku G Iwata Atsushi A Tagawa Kazuhiko K Atsuta Naoki N Katsuno Masahisa M Tomita Naoki N Furukawa Katsutoshi K Saito Yuko Y Saito Takashi T Ichise Ayaka A Shibata Shinsuke S Arai Hiroyuki H Saido Takaomi T Sudol Marius M Muramatsu Shin-Ichi SI Okano Hideyuki H Mufson Elliott J EJ Sobue Gen G Murayama Shigeo S Okazawa Hitoshi H
Nature communications 20200124 1
The timing and characteristics of neuronal death in Alzheimer's disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), and reveal an increase of neuronal necrosis during pre-symptomatic phase and a subsequent decrease during symptomatic phase. Postmortem brains of mild cognitive impairment (MCI) rather than symptomatic AD patients reveal a remarkable increase of necro ...[more]
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